Interleukin-1-induced cartilage degradation: involvement of gas mediators.
نویسندگان
چکیده
منابع مشابه
Degradation of Extracellular Matrix Molecules in Interleukin-1 Alpha Treated Bovine Nasal Cartilage
Background: This work aimed to show and compare the degradation time of some of cartilage extracellular matrix components using an in vitro model for cartilage degradation induced by interleukin-1 alpha. It is known that elucidation of molecular events under Interleukin-1 alpha induction of bovine nasal cartilage could obtain useful data to understand more about involving mechanisms for tissue ...
متن کاملCombination Effects of Prednisolone and Interleukin-4 Protect Bovine Nasal Cartilage Explants from Interleukin-1α Induced Degradation
Background: Current treatments for joint diseases are moderately successful, but unfortunately are associated with significant side effects. This study was undertaken to investigate the combination effects of IL-4 and prednisolone on tissue characteristics and production of matrix metalloproteinase-1(MMP-1) in IL-lα-treated bovine nasal cartilage (BNC) explants. Methods: BNC explants were cultu...
متن کاملdegradation of extracellular matrix molecules in interleukin-1 alpha treated bovine nasal cartilage
background: this work aimed to show and compare the degradation time of some of cartilage extracellular matrix components using an in vitro model for cartilage degradation induced by interleukin-1 alpha. it is known that elucidation of molecular events under interleukin-1 alpha induction of bovine nasal cartilage could obtain useful data to understand more about involving mechanisms for tissue ...
متن کاملPannus invasion and cartilage degradation in rheumatoid arthritis: involvement of MMP-3 and interleukin-1beta.
OBJECTIVE Synovial inflammation in rheumatoid arthritis (RA) leads to pannus tissue invasion and destruction of cartilage/bone matrix by proteinases. Our intention was to analyze some of the key matrix metalloproteinases (MMPs) in pannus tissue overlying evolving cartilage erosions in RA. METHODS Frozen tissue samples of pannus and synovium from advanced RA and synovium from osteoarthritic pa...
متن کاملcombination effects of prednisolone and interleukin-4 protect bovine nasal cartilage explants from interleukin-1α induced degradation
background: current treatments for joint diseases are moderately successful, but unfortunately are associated with significant side effects. this study was undertaken to investigate the combination effects of il-4 and prednisolone on tissue characteristics and production of matrix metalloproteinase-1(mmp-1) in il-lα-treated bovine nasal cartilage (bnc) explants. methods: bnc explants were cultu...
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ژورنال
عنوان ژورنال: Ensho
سال: 1996
ISSN: 0389-4290,1884-4006
DOI: 10.2492/jsir1981.16.85